Copula modeling of gene coexpression in single-cell RNA sequencing data.

ABSTRACT: Single-cell RNA sequencing (scRNA-seq) has become an indispensable tool for studying biological systems at the cellular level. It has therefore has become increasingly important to develop accurate statistical models of scRNA-seq data. While many models have been proposed to characterize transcript expression of individual genes, comparatively little attention has been paid to modeling gene coexpression. Copula modeling offers a flexible approach to modeling gene coexpression by linking models of individual genes together using copula functions. Despite the growing popularity of copula models, their utility for modeling scRNA-seq data has not been thoroughly explored. Here we evaluated six copula models on their ability to model gene coexpression in scRNA-seq data. Using a diverse collecti

SUBMITTER: Puritz C 

PROVIDER: S-EPMC12710820 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature