Candida albicans sterol C-14 reductase, encoded by the ERG24 gene, as a potential antifungal target site.

ABSTRACT: The incidence of fungal infections has increased dramatically, which has necessitated additional and prolonged use of the available antifungal agents. Increased resistance to the commonly used antifungal agents, primarily the azoles, has been reported, thus necessitating the discovery and development of compounds that would be effective against the major human fungal pathogens. The sterol biosynthetic pathway has proved to be a fertile area for antifungal development, and steps which might provide good targets for novel antifungal development remain. The sterol C-14 reductase, encoded by the ERG24 gene, could be an effective target for drug development since the morpholine antifungals, inhibitors of Erg24p, have been successful in agricultural applications. The ERG24 gene of Candida albica

SUBMITTER: Jia N 

PROVIDER: S-EPMC127109 | biostudies-literature | 2002 Apr

REPOSITORIES: biostudies-literature