Influenza hemagglutinin and neuraminidase multivalent vaccine elicits broader protective immune responses compared to vaccine formulations composed of hemagglutinin or neuraminidase.

ABSTRACT: Developing a more effective seasonal influenza vaccine is necessary to reduce the global health and economic burdens caused by influenza virus infections. Next-generation influenza vaccines using computationally optimized broadly reactive antigen (COBRA) methodology elicit protective immune responses against strains over multiple seasons. Most influenza virus vaccines are currently administered intramuscularly and elicit systemic immune responses. Intranasal administration elicits mucosal immune responses at the site of infection, as well as systemic immunity. It was hypothesized that COBRA-derived hemagglutinin and/or neuraminidase recombinant protein combined with the c-di-AMP adjuvant will elicit broadly reactive mucosal and systemic immune responses when administered intranasally again

SUBMITTER: Uno N 

PROVIDER: S-EPMC12710908 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature