Pre-vaccine immune profiling in cancer patients identifies correlates of COVID-19 vaccine responses.

ABSTRACT: mRNA vaccines have been highly effective against SARS-CoV-2-related severe illness and are currently undergoing investigation as anti-cancer therapeutics. Our prior work has shown that patients undergoing cancer therapy have reduced immune responses to mRNA-based vaccines. Therefore, further investigation into immunologic responses in the setting of immune-altered hosts is warranted. In this study, we investigated pre-vaccination peripheral immune cell repertoire from a cohort of 66 patients with cancer on active treatment. Immune cell repertoire was characterized by mass cytometry to identify key immune subsets for COVID-19 vaccine response. Immunological populations were then assessed for their association with spike-specific antibody titers measured by ELISA and the breadth and depth of

SUBMITTER: Kazerani M 

PROVIDER: S-EPMC12710909 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature