GPR41 deficiency alters the gut microbiota-bile acid axis, reduces ileal expression of <i>Npc1l1</i>, and attenuates hypercholesterolemia in male mice.

ABSTRACT: Hypercholesterolemia contributes to the development of atherosclerosis and is a major risk factor for cardiovascular diseases (CVD). Dietary fiber can attenuate CVD, at least in part, by serving as a fermentable substrate for gut bacteria, leading to the production of short-chain fatty acids (SCFAs), such as butyrate and propionate, which have been linked to atheroprotective effects. SCFAs are sensed by G-protein coupled receptors including GPR41, GPR43, and GPR109A. To explore the role of these receptors in hypercholesterolemia and CVD, we examined atherosclerosis progression and lipid metabolism in Gpr41^-/-, Gpr43^-/-, and Gpr109a^-/- mice using a proprotein convertase subtilisin/kexin type 9 adeno-associated virus

SUBMITTER: Hutchison ER 

PROVIDER: S-EPMC12710913 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature