<b>Food-residue-level antibiotics promote mucosal colonization of foodborne antibiotic-resistant</b> <i><b>Staphylococcus aureus</b></i> <b>in a simulated human gut</b>.

ABSTRACT: Antibiotic-resistant bacteria (ARB) and food-residue-level antibiotics in food can disrupt gut homeostasis. However, the impact of co-exposure with food-residue-level antibiotics on compartment-specific colonization dynamics and associated risks of ARB in human gut remains unclear. Here, we isolated a ciprofloxacin (CIP)-resistant Staphylococcus aureus strain from edible fish parts in aquaculture environment and assessed exposure risks to luminal and mucosal microbiotas using the in vitro Mucosal Simulator of the Human Intestinal Microbial Ecosystem (M-SHIME; ProDigest, Belgium) under three treatments: S. aureus alone, food-residue-level CIP alone, and co-exposure to both. Food-residue-level CIP promoted the potential colonization of S. aureus and relative abund

SUBMITTER: Yan Z 

PROVIDER: S-EPMC12710920 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature