Tex15 is required for vomeronasal sensory neuron diversity and male pheromone detection.

ABSTRACT: The mouse vomeronasal organ (VNO) detects pheromones, which provide vital information needed to find a mate, detect predators, or alert to the presence of an intruder. Within the VNO, pheromones are sensed by two families of G-protein Coupled Receptors (GPCRs) the type 1 and type 2 vomeronasal receptors (V1Rs and V2Rs). However, little is known about the regulatory mechanisms that control the expression of V1R and V2R by vomeronasal sensory neurons (VSNs). Here we show that VSN precursors transiently express Testes-expressed gene 15 (Tex15), which in the germline is required to repress the expression of transposable elements during spermatogenesis. We find that the absence of Tex15 results in a dysregulated VR choice for V1Rs and A, B, and D family V2Rs, which manifest

SUBMITTER: Boutros Ghali N 

PROVIDER: S-EPMC12710957 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature