A subject-specific reversible folding model reveals geometry-driven white-matter organization.

ABSTRACT: Tractography currently relies almost exclusively on diffusion data and seed maps, which alone remain insufficient for anatomically accurate fiber reconstruction. During brain development, white-matter fibers elongate alongside cortical folding, suggesting a close mechanistic link between cortical geometry and fiber organization. To investigate this link, we introduce a subject-specific cortical folding simulation framework that reconstructs an individual's folding trajectory using only a structural T1-weighted image. The quasi-static, constraint-based model reverses folding to generate an unfolded, fetal-like configuration and then refolds to map the resulting volumetric deformation onto fiber organization. Validation with longitudinal fetal MRI shows that simulated folds follow biological

SUBMITTER: Osman B 

PROVIDER: S-EPMC12710974 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature