Electrophysiological fingerprints of healthy cervical epithelial and HeLa cells: Membrane potential, zeta potential and passive electrical properties.

ABSTRACT: There is a growing appreciation that cellular electrical mechanisms play an important role both in cell regulation, and in cell dysregulation in diseases such as cancer. These electrical mechanisms are measured using several different methods, which yield characteristics including the membrane potential, capacitance and conductance, the extracellular (ζ) potential and cytoplasm conductivity. However, since these are measured using different techniques, the combination of all of these (the cancer electrome) has yet to be described. In this paper, we report on the difference between the electromes of cervical cancer cell line HeLa, with clinically-derived primary cervical epithelial cells. These were investigated using dielectrophoresis (DEP) and ζ-potential, with these data then being used

SUBMITTER: Hoque R 

PROVIDER: S-EPMC12711043 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature