Endothelial Slit2 guides the Robo1-positive sympathetic innervation during heart development.

ABSTRACT: Axon guidance cues direct nerves in the heart during development, disease, and regeneration. These cues determine cardiac innervation patterning by regulating the balance between chemo-attraction and chemo-repulsion. However, the role of one of the most crucial ligand-receptor combinations among axon guidance molecules, the Slit chemo-active ligands and their Roundabout (Robo) transmembrane receptors, remains unknown during cardiac innervation patterning. To test if Slit-Robo signalling is important for cardiac innervation guidance, we analysed Slit and Robo mouse knock-outs. Constitutive Slit2^-/- ventricles showed significantly reduced innervation, while Slit3^-/- hearts showed temporary increased levels of innervation compared to wild-type littermate co

SUBMITTER: Zhao J 

PROVIDER: S-EPMC12711195 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature