Mass, mobility and MSⁿ measurements of single ions using charge detection mass spectrometry.

ABSTRACT: Charge detection mass spectrometry is used to measure the mass, charge, MSⁿ and mobility of an individual ion produced by electrospray ionization of a 8 MDa polyethylene glycol sample. The charge detection mass spectrometer is an electrostatic ion trap that uses cone electrodes and a single tube detector and can detect ions for up to the full trapping time of 4.0 s. The time-domain signal induced on the detector tube by a single multiply charged ion can be complex owing to sequential fragmentation of the original precursor ion as well as increasing oscillation frequencies of the single ion owing to collisions with background gas that reduce the kinetic energy of the ion inside the trap. Simulations show that the ratio of the time for the ion to turn around inside the cone region

SUBMITTER: Elliott AG 

PROVIDER: S-EPMC12711220 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature