Collisional Cross-Sections with T-Wave Ion Mobility Spectrometry without Experimental Calibration.

ABSTRACT: A method for relating traveling-wave ion mobility spectrometry (TWIMS) drift times with collisional cross-sections using computational simulations is presented. This method is developed using SIMION modeling of the TWIMS potential wave and equations that describe the velocity of ions in gases induced by electric fields. The accuracy of this method is assessed by comparing the collisional cross-sections of 70 different reference ions obtained using this method with those obtained from static drift tube ion mobility measurements. The cross-sections obtained here with low wave velocities are very similar to those obtained using static drift (average difference = 0.3%) for ions formed from both denaturing and buffered aqueous solutions. In contrast, the cross-sections obtained with high wave v

SUBMITTER: Mortensen DN 

PROVIDER: S-EPMC12711221 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature