RETINAL PHOTORECEPTORS AND ARTERIOLES ALTERATIONS DETECTED USING ADAPTIVE OPTICS SCANNING LASER OPHTHALMOSCOPY IN DIABETES AND DIABETIC RETINOPATHY.

ABSTRACT:

Purpose

To detect retinal photoreceptors and arterioles alterations among individuals with diabetes mellitus (DM) and nonproliferative diabetic retinopathy (DR) at cellular resolution.

Methods

Thirty subjects were recruited in the Guangdong Diabetic Retinopathy Multiple-omics Study. Adaptive optics scanning laser ophthalmoscopy was adopted for image acquisition. An AI-based algorithm conducted quantitative analyses of photoreceptor morphology, including cone density, spacing, and regularity. Vessel morphology (inner diameter, outer diameter, wall thickness, wall-to-lumen ratio) was manually assessed. The arteriolar index ratio was derived to assess arteriolar remodeling. Generalized estimating equation was used to compare the differences of inner diameter, outer diameter, wa

SUBMITTER: Su T 

PROVIDER: S-EPMC12711260 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature