The Impact of Genome-wide Histocompatibility on Liver Transplantation Outcomes.

ABSTRACT:

Background

Liver transplantation (LT) is the standard treatment for end-stage liver diseases. However, the role of HLA matching in LT remains unclear. Immunological allograft injury and rejection are ongoing concerns, particularly when efforts are made to minimize immunosuppression. Although HLA matching currently has no established role in LT, interest in non-HLA compatibility in the field of transplantation is growing. We compared 666 LT recipient-donor pairs and identified amino acid-changing genetic mismatches outside the HLA gene segment in different protein groups and mismatches in 40 common gene deletions.

Methods

We evaluated the association between mismatches and LT outcomes by using adjusted Cox models for missense variant mismatches and deletion analyses. The prim

SUBMITTER: Semenova M 

PROVIDER: S-EPMC12711261 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature