Temporal Proteomic Remodeling of Cerebral Arteries in Male Hypertensive Rats.

ABSTRACT:

Background

Hypertension is a significant risk factor for several neurological disorders, including stroke and dementia, yet the molecular mechanisms underlying these risks remain poorly understood. In this study, we investigated temporal proteomic remodeling of the cerebrovasculature in male spontaneously hypertensive rats and normotensive Wistar-Kyoto controls at 30 and 40 weeks of age, representing the effect of untreated hypertension from early adulthood to midlife.

Methods

Using male 30- and 40-week-old spontaneously hypertensive rats and Wistar-Kyoto rats, we have performed discovery-based proteomics, histological imaging, and RNA-sequencing data analysis.

Results

Proteomic analysis displayed a significant age-dependent change in the protein composition of the ce

SUBMITTER: Bastrup JA 

PROVIDER: S-EPMC12711280 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature