Serine Glycine Restriction Aggravates Hepatic Ischemia-reperfusion Injury.

ABSTRACT:

Background

Hepatic ischemia-reperfusion injury (HIRI) significantly affects liver function in liver transplantation, primarily through dysregulated metabolism and inflammation. Although serine and glycine (SG) have been identified as potential therapeutic targets in various diseases, the mechanisms by which SG influences HIRI remain unclear. This study aimed to investigate the effects of SG deficient (-SG) dietary intervention on HIRI.

Methods

We established an in vivo and in vitro HIRI model under the -SG condition. RNA sequencing, coupled with bioinformatics analysis, identified key targets modulated after -SG intervention. Biochemical and histological analyses were used to evaluate the effects of -SG on HIRI. Furthermore, plasmid-based transient overexpression of CYP2S1 a

SUBMITTER: Yang M 

PROVIDER: S-EPMC12711281 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature