Circulating Cardiovascular Proteomic Associations With Genetics and Disease.

ABSTRACT:

Background

The analysis of the circulating proteome can identify translational modifiers and biomarkers of disease expressivity and severity at a given time point. Here, we explore the relationships between protein measures implicated in cardiovascular disease and whether they mediate causal relationships between cardiovascular risk factors and disease development.

Methods

To understand the relationships between circulating biomarkers and genetic variants, medications, anthropometric traits, lifestyle factors, imaging-derived measures, and diagnoses of cardiovascular disease, we undertook in-depth analyses of measures of 9 plasma proteins with a priori roles in genetic and structural cardiovascular disease or treatment pathways (ACE2 [angiotensin-converting enzyme 2], ACTA2

SUBMITTER: McGurk KA 

PROVIDER: S-EPMC12711284 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature