Pulmonary and Extrapulmonary Effects of Prolonged Prone Positioning in a Porcine Model of Acute Respiratory Distress Syndrome.

ABSTRACT:

Background

Prone positioning (PP) improves survival in severe acute respiratory distress syndrome (ARDS), but its prolonged effects on pulmonary and extrapulmonary organs remain unclear. This study aimed to investigate the pathophysiological effects of 24-h PP in a porcine ARDS model.

Methods

Ten female Bama mini swine (49.5 ± 3.7 kg) underwent severe ARDS induction via repeated saline lavage and were randomized to PP (n = 5) or supine position (SP, n = 5). Respiratory parameters, electrical impedance tomography, hemodynamics, and biochemical serum analysis were performed. After 24 h, regional lung injury was assessed via histopathology and wet-dry weight ratio, and extrapulmonary injury was evaluated by histopathology, apoptosis, oxidative stress, and organ-specific injury

SUBMITTER: Bian Y 

PROVIDER: S-EPMC12711290 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature