Single-cell transcriptome analyses reveal disturbed decidual microenvironment in women of advanced maternal age.

ABSTRACT:

Background

Advanced maternal age (AMA) increases pregnancy risk. However, uterine-specific mechanisms independent of oocyte and embryo quality remain poorly defined. This study aimed to characterise the decidual microenvironment in women with AMA to identify key pathological changes and regulatory pathways.

Methods and results

Through integrated histology, organoid modelling, and high-resolution scRNA-seq of first-trimester decidua from women of AMA and controlled reproductive age, we uncovered a pathologically remodelled decidual microenvironment characterised by aberrant cellular states and pathological differentiation pathways, leading to a pro-fibrotic state and accompanied by immune cell dysfunction, and disrupted intercellular communication in the AMA decidua. Central

SUBMITTER: Xie H 

PROVIDER: S-EPMC12711380 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature