Endocrine-disrupting effects of environmental BPS and PFOS on human brain organoid development.

ABSTRACT:

Objective

Prenatal exposure to environmental endocrine-disrupting chemicals (EDCs) has been increasingly linked to neurodevelopmental impairment. Bisphenol S (BPS) and perfluoro-octane sulfonate (PFOS), two widely distributed EDCs detected in maternal and fetal tissues, raise concern due to their potential to interfere with brain development even at low environmental doses.

Methods

a phenotypic screening on human iPSC-derived cerebral organoids was performed to explore whether chronic exposure to BPS and PFOS could affect key neurodevelopmental processes.

Results

Both compounds affected key neurodevelopmental processes, including neuronal proliferation, cortical specification, synaptogenesis, glutamatergic differentiation, mitochondrial function, and choroid plexus fo

SUBMITTER: Di Credico A 

PROVIDER: S-EPMC12711465 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature