Real-world 12-month outcomes of repeated high-concentration capsaicin patch in chemotherapy-induced peripheral neuropathy: results from the CASPAR study.

ABSTRACT:

Background

Chemotherapy-nduced peripheral neuropathy (CIPN) is a frequent and debilitating complication of cancer therapy, often leading to chronic pain, impaired quality of life (QoL), and reduced daily functioning. This study evaluated the long-term effectiveness and safety of repeated high-concentration capsaicin patch (HCCP) treatment for CIPN using real-world data from the German Pain e-Registry (GPeR).

Methods

In this retrospective, observational, non-randomized cohort study, 169 CIPN patients who received one to four HCCP treatments were followed at 3-monthly intervals (± 2 weeks) over 12 months. Assessed outcomes included average 24-hour pain intensity (API), QoL, sleep, emotional well-being, daily functioning, analgesic use, and safety.

Results

Of 169 patient

SUBMITTER: Uberall MA 

PROVIDER: S-EPMC12711474 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature