Transcriptional insights into gastrointestinal adaptations in pigs to high altitude.

ABSTRACT: Characterizing the transcriptomic profiles of gastrointestinal tract tissues in high-altitude pigs is crucial for understanding the molecular mechanisms underlying their metabolic adaptation to high-altitude environments. Here, we generated RNA-seq data from five gastrointestinal tract tissues (i.e., stomach, jejunum, cecum, colon, rectum) and the triceps brachii muscle of six 300-day-old castrated male Tibetan pigs (inhabiting high-altitude regions) and six Black pigs (inhabiting low-altitude regions). Pigs were group-housed and fasted for 24 h before sampling. We identified transcriptional differences between these two pig populations, revealing that genes upregulated in the gastrointestinal tract tissues and triceps brachii muscle of Tibetan pigs, compared to Black pigs, are primarily a

SUBMITTER: Ran B 

PROVIDER: S-EPMC12711528 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature