Clinicopathological data and the role of miRNA expression in patients with pheochromocytomas/paragangliomas.

ABSTRACT:

Background

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors with variable behavior and metastatic potential. Reliable prognostic biomarkers are needed to improve risk stratification and long-term management. Emerging data suggest a role for microRNAs (miRNAs) and immune checkpoint pathways (or inhibitors) in tumor aggressiveness.

Objective

To evaluate the expression of five candidate miRNAs (miR-15a, miR-16, miR-101, miR-183, and miR-483-5p) and programmed death ligand-1 (PD-L1) in PPGL tissues, and assess their associations with clinicopathological features, genetic status and outcomes.

Methods

A retrospective cohort of 130 patients with PPGLs was analyzed, including 53 PPGL tumor and 20 normal adrenal medulla tissues (controls). MiRNA expr

SUBMITTER: Thanasoula F 

PROVIDER: S-EPMC12711539 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature