Comparative study of eGFR in cancer and non-cancer individuals: a multicenter analysis.

ABSTRACT:

Background

Cancer is the second leading cause of death worldwide, and renal impairment frequently occurs during its course and treatment due to nephrotoxic chemotherapy and contrast exposure. Understanding baseline estimated glomerular filtration rate (eGFR) and its longitudinal changes in cancer patients is essential for effective kidney function management.

Methods

This multicenter study included 24,478 treatment-naïve cancer patients admitted to three cancer centers in 2018 and 61,883 non-cancer individuals undergoing health screening in the same year, with follow-up until 2023. eGFR was calculated using the CKD-EPI equation. Baseline eGFR and subsequent changes were compared between groups after stratification by age, sex, and comorbidity.

Results

Across all age g

SUBMITTER: Ye B 

PROVIDER: S-EPMC12711550 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature