Cross-frequency coupling patterns during oddball processing in disorders of consciousness: a delta-gamma predominance.

ABSTRACT:

Background

Phase-amplitude coupling (PAC) between low- and high-frequency oscillations provides a candidate mechanism for integrating information across cortical networks. While PAC alterations have been reported in disorders of consciousness (DOC), the frequency specificity and task dependence of these changes remain poorly characterized.

Objective

To systematically examine cross-frequency coupling patterns during auditory oddball processing in DOC patients and explore whether specific frequency combinations or frequency shifts are associated with different levels of consciousness.

Methods

Sixty-two participants [20 healthy controls (HC), 21 minimally conscious state (MCS), 21 unresponsive wakefulness syndrome (UWS)] underwent EEG recording during an auditory oddball

SUBMITTER: Huang B 

PROVIDER: S-EPMC12711717 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature