Advances and challenges in plant N-glycoengineering: when fucosylation matters.

ABSTRACT: Plant-based expression systems have emerged as promising platforms to produce recombinant glycoproteins. Transient recombinant protein production is a promising alternative to stable transgenic systems, particularly for emergency situations in which rapid production of novel therapeutics is needed. A potential barrier for plant-based production of therapeutic proteins is that different glycosylation patterns are found on plants. Nevertheless, advances in glycoengineering, particularly in the generation of glycoproteins bearing human- and helminth-like N-glycans, further support the use of plants as valuable systems for biopharmaceutical manufacturing. Glyco-design, including methods to control glycan structures and distributions in plants, is a powerful tool for optimizing the efficacy of

SUBMITTER: Gauba K 

PROVIDER: S-EPMC12711721 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature