Autoimmune thyroid disease and human health: a systematic review of Mendelian randomization studies.

ABSTRACT: We systematically summarized current Mendelian randomization (MR) evidence on the causal relationships between autoimmune thyroid disease (AITD) and a wide range of human health outcomes. Original MR studies related to AITD published up to March 1, 2025, were retrieved from PubMed and Embase. For studies investigating the same exposure-outcome associations, meta-analyses were performed to synthesize the evidence after excluding overlapping samples where applicable. The methodological quality of the included studies was assessed using the STROBE-MR checklist. A total of 123 MR publications met the inclusion criteria. MR analyses indicated that AITD significantly increased the risk of coronary atherosclerosis, deep venous thrombosis, chronic obstructive pulmonary disease, major depression, d

SUBMITTER: Li P 

PROVIDER: S-EPMC12711731 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature