Predictive value of Th17/Treg immune imbalance for disease severity and poor prognosis in children with respiratory syncytial virus pneumonia.

ABSTRACT:

Objective

Respiratory syncytial virus pneumonia (RSVP) remains a major cause of pediatric hospitalization. This study evaluates the value of Th17/Treg imbalance in assessing disease severity and predicting prognosis among RSVP children.

Methods

RSVP children (422 cases) during May 2022-May 2024 were retrospectively enrolled and divided into mild and moderate-to-severe groups based on disease severity. Additionally, 358 healthy children were recruited (the control group). Peripheral blood Th17 and Treg cell proportions were quantified by flow cytometry, with the Th17/Treg ratio calculated. Serum IL-17, IL-6, IL-10, and TGF-β1 levels were measured using ELISA. Logistic regression models were established to identify risk factors for poor prognosis. ROC curves were plotted to ev

SUBMITTER: Zhu M 

PROVIDER: S-EPMC12711749 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature