Association between red blood cell distribution width coefficient of variation and post-treatment bilirubin decline velocity in neonatal hyperbilirubinemia.

ABSTRACT:

Background

Red blood cell distribution width coefficient of variation (RDW-CV) reflects erythrocyte heterogeneity, but its correlation with posttreatment bilirubin kinetics in neonatal hyperbilirubinemia (NHB) remains underexplored.

Methods

This cross-sectional study analyzed 803 neonates (≥35 weeks of gestation) with NHB. RDW-CV was measured at admission, and bilirubin decline velocity was calculated during phototherapy. Associations were evaluated using multivariate linear regression and restricted cubic splines, adjusted for demographic, maternal, and hematologic factors.

Results

Each 1% RDW-CV increase independently reduced bilirubin decline velocity by 2.04 μmol/(L·day) (β = -2.04, 95% CI: -3.48∼-0.60, P = 0.006). Compared with neonates in the lowes

SUBMITTER: Wei H 

PROVIDER: S-EPMC12711753 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature