Risk of uveitis among children with autoimmune diseases: a nationwide matched-cohort study of 3,643 cases.

ABSTRACT:

Background

Pediatric uveitis, though accounting for less than 10% of all uveitis cases, presents significant diagnostic and therapeutic challenges due to its asymptomatic onset and potential for severe, vision-threatening complications. Despite known associations with autoimmune diseases, data on risk factors in Asian pediatric populations remain limited. This study aimed to quantify the risk of uveitis in Taiwanese children with autoimmune diseases, identify key comorbidities, and evaluate the effects of immunosuppressive therapies.

Methods

Using Taiwan's National Health Insurance Research Database (2009-2019), we conducted a nationwide retrospective cohort study of 3,643 pediatric patients with autoimmune diseases matched 1:1 to controls. Patients were followed for up to 1

SUBMITTER: Liu DY 

PROVIDER: S-EPMC12711771 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature