Peripheral <i>CHI3L1</i> expression is associated with APOE ε4 status in early-onset Alzheimer's disease.

ABSTRACT:

Background

YKL-40 (CHI3L1) is a glycoprotein secreted by reactive astrocytes and peripheral immune cells, implicated in inflammation and tissue remodeling in Alzheimer's disease (AD). While elevated CHI3L1 levels have been observed in cerebrospinal fluid and plasma, its expression at the transcript level in peripheral blood - and modulation by genetic risk factors such as APOE ε4 - remains poorly understood.

Methods

We analyzed peripheral blood CHI3L1 mRNA expression in a well-characterized cohort comprising individuals with biomarker-confirmed AD (n = 34), mild cognitive impairment (MCI; n = 31), and cognitively healthy controls (HC; n = 21). CHI3L1 expression levels were compared across diagnostic groups and stratifie

SUBMITTER: Steinmaurer A 

PROVIDER: S-EPMC12711778 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature