Effectiveness and safety of tocilizumab in refractory noninfectious uveitis: a systematic review and meta-analysis.

ABSTRACT:

Purpose

The aim of this study was to comprehensively evaluate the efficacy and safety of tocilizumab in patients with refractory noninfectious uveitis (NIU) through a systematic review and meta-analysis.

Methods

A comprehensive literature search was conducted across PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov from inception to 13 July 2025. Eligible studies included case series and cohort studies evaluating clinical outcomes of tocilizumab in NIU. Study quality was assessed using the Joanna Briggs Institute Case Series Checklist and Newcastle-Ottawa Scale. A single-arm meta-analysis was performed using a random-effects model.

Results

Thirteen studies involving 374 patients were included. The pooled rate of sustained inactive uveitis was 57

SUBMITTER: Kang H 

PROVIDER: S-EPMC12711790 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature