Physiologically-based pharmacokinetic modeling and simulation for initial dose optimization of levetiracetam in pediatrics.

ABSTRACT:

Introduction

Optimizing levetiracetam (LEV) dosing in children is challenging due to high pharmacokinetic variability, which often necessitates empirical dose titration. This study aimed to develop and verify a physiologically-based pharmacokinetic (PBPK) modeling and simulation to guide and optimize initial LEV dose selection in pediatric patients.

Methods

A whole-body PBPK model for LEV was developed and verified in adults, then scaled and verified in a pediatric population (0.5-12 years). This model was used to simulate various dosing regimens. Subsequently, a multivariate linear regression (MLR) analysis correlated key covariates (dose, regimen, body weight, and glomerular filtration rate) with simulated steady-state peak (C_max) and trough (C_tr) con

SUBMITTER: Macente J 

PROVIDER: S-EPMC12711802 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature