Coexistence of anti-neurexin-3α-associated autoimmune encephalitis and systemic lupus erythematosus in an adult patient: a case report.

ABSTRACT: Autoimmune encephalitis (AE) associated with anti-neurexin-3α antibodies, an uncommon variant of AE, exhibits particularly low frequency when coexisting with systemic immune dysregulation. The heterogeneous clinical manifestations of this neuroinflammatory disorder hinder timely diagnosis. We describe a 55-year-old male diagnosed with anti-neurexin-3α-associated AE, complicated by systemic lupus erythematosus (SLE) and antiphospholipid antibodies. The case presented with pyrexia persisting for 3 days, followed by acute-onset vertigo and encephalopathy evolving over 7 h. The clinical course was marked by visual obscuration, cephalalgia with associated emetic episodes, and concurrent neuropsychiatric manifestations, including psychomotor agitation and urinary incontinence. Anti-neurexin-3α a

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12711809 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature