Identification of a ubiquitin-binding domain protein, CD2AP, in predicting the prognosis and treatment of lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma remains a leading cause of cancer mortality, necessitating novel prognostic biomarkers and therapeutic targets. Ubiquitination, a crucial post-translational modification, is deeply implicated in tumourigenesis. This study aims to identify key ubiquitination-related regulators in LUAD and investigate their clinical significance, with a particular focus on CD2AP.

Methods

We analysed transcriptomic data from TCGA and GEO databases to identify survival-related ubiquitination genes. Proteomic data from the CPTAC database validated key findings. Functional enrichment, immune cell infiltration, and single-cell RNA sequencing (scRNA-seq) analyses were performed to explore the role of CD2AP. Drug sensitivity and molecular docking were used

SUBMITTER: Dai Q 

PROVIDER: S-EPMC12711811 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature