Metabolomic analysis of <i>Streptococcus pneumoniae</i>: uncovering key metabolic pathways.

ABSTRACT:

Background

Pneumococcal infection, caused by Streptococcus pneumoniae, is a prevalent cause of community-acquired pneumonia and a major pathogen responsible for illnesses such as meningitis, sepsis, and pharyngitis. The complex etiology of S. pneumoniae infection poses significant challenges in elucidating the molecular mechanisms underlying its pathogenesis.

Methods

In this study, twenty serum samples from individuals infected with S. pneumoniae and fifteen serum samples from normal controls were analyzed using liquid chromatography/mass spectrometry (LC-MS) to identify metabolites. Multivariate statistical analyses, including principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA), were used to identify p

SUBMITTER: Jiang H 

PROVIDER: S-EPMC12711820 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature