Nomogram to predict 5-year global cognitive impairment in <i>de novo</i> Parkinson disease with normal cognition at baseline.

ABSTRACT:

Background and objective

Cognitive impairment (CI, combing mild cognitive impairment and dementia) seriously affects the quality of life in patients with de novo Parkinson disease (PD). The aim of the present study was to identify the potential predictive factors for 5-year cognitive decline in de novo PD.

Methods

Parkinson's Progression Marker Initiative (PPMI) database was retrieved and PD patients with normal global cognition at baseline were included. These patients were divided into normal cognitive (NC) group and CI group based on their Montreal Cognitive Assessment (MoCA) scores at the 5-year follow-up period. A total of 66 baseline variables were compared between these two groups. Univariate and multivariate logistic regression analyses were conducted,

SUBMITTER: Wang X 

PROVIDER: S-EPMC12711850 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature