Fourier transform infrared spectroscopy detects distinct TAR DNA-binding protein 43 signatures in frontotemporal lobar degeneration.

ABSTRACT:

Background

Frontotemporal lobar degeneration (FTLD) is a leading cause of cognitive impairment in young adults. A major pathological subtype of FTLD is characterized by positive expression of TAR DNA Binding Protein 43 (TDP-43), referred to as FTLD[TDP]. However, techniques that can be utilized to interrogate and distinguish between various subtypes of FTLD are limited. Herein, we evaluated the potential of Fourier transform infrared (FTIR) spectroscopy to inform on the biomolecular changes in FTLD and to discriminate this disease from other non-FTLD cases.

Methods

Histopathologically confirmed cases from FTLD[TDP] and Alzheimer's disease (AD) autopsy cases were evaluated using FTIR spectroscopy. Formalin-fixed paraffin-embedded (FFPE) brain tissue sections from the superior

SUBMITTER: Gatto RG 

PROVIDER: S-EPMC12711859 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature