Pan immune inflammation value improves MELD 3.0 for mortality prediction in critically ill cirrhotic patients.

ABSTRACT: Liver cirrhosis poses a significant global health burden, with over 100 million cases worldwide and 2 million annual deaths. Despite advances in prognostic tools like MELD 3.0, their performance remains suboptimal. The pan-immune-inflammation value (PIV), a novel biomarker of systemic inflammation, has shown prognostic utility in chronic diseases but remains underexplored in cirrhosis. This study evaluates PIV's predictive value for mortality in critically ill cirrhotic patients and its synergy with MELD 3.0. Using data from the MIMIC-IV database, we analyzed 2,399 critically ill cirrhotic patients. PIV was calculated as neutrophils × platelets × monocytes/lymphocytes. Primary and secondary endpoints were 28-day and 365-day all-cause mortality, respectively. Multivariable Cox models, restr

SUBMITTER: Zhu L 

PROVIDER: S-EPMC12711914 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature