Identifying compounds to treat opiate use disorder by leveraging multi-omic data integration and multiple drug repurposing databases.

ABSTRACT: Genes influencing opioid use disorder (OUD) biology have been identified via genome-wide association studies (GWAS), gene expression, and network analyses. These discoveries provide opportunities to identifying existing compounds targeting these genes for drug repurposing studies. However, systematically integrating discovery results and identifying relevant available pharmacotherapies for OUD repurposing studies is challenging. To address this, we've constructed a framework that uses existing results and drug databases to identify candidate pharmacotherapies. For this study, two independent OUD related meta-analyses were used including a GWAS and a differential gene expression (DGE) study of post-mortem human brain. Protein-Protein Interaction (PPI) sub-networks enriched for GWAS risk loc

SUBMITTER: Stratford JK 

PROVIDER: S-EPMC12711988 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature