AI-aided identification of dual-purpose therapeutic targets PRPF19 and MAPK9 in hepatocellular carcinoma and cellular senescence.

ABSTRACT: Hepatocellular carcinoma (HCC) is one of the most prevalent and malignant forms of primary liver cancer, with limited therapeutic options and a poor prognosis. Cellular senescence contributes to the progression of chronic liver disease while creating a microenvironment that supports tumor growth. This study aims to identify dual-purpose therapeutic targets for HCC treatment and cellular senescence intervention, potentially leading to more effective therapeutic strategies. Utilizing the AI-driven target discovery platform PandaOmics, we prioritized 27 high-confidence, and 8 novel HCC targets potentially associated with cellular senescence. Experimental validations confirmed that the knockdown of pre-mRNA-processing factor 19 (PRPF19) or mitogen-activated protein kinase 9 (MAPK9) in HCC cell

SUBMITTER: Ren C 

PROVIDER: S-EPMC12712000 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature