Temporal trends and disparities in stroke and diabetes mellitus comorbidity-related mortality from 1999 to 2023.

ABSTRACT: Stroke and diabetes mellitus (DM) frequently co-occur and interact through shared vascular and metabolic pathways. The comorbidity-related mortality patterns of the two diseases and the disparities across different subgroups remain insufficiently investigated on a global scale. This study aims to explore these trends using a nationally representative mortality database. We examined mortality statistics from the CDC WONDER database (1999-2023), incorporating deaths where stroke or DM was listed as an underlying or contributing condition. Age-adjusted mortality rates (AAMR) per 100,000 were computed using the 2000 U.S. Census standard. Joinpoint regression analysis assessed annual percentage change (APC) and average APC (AAPC) with 95% confidence intervals, stratified by age, sex, race/ethni

SUBMITTER: Ma H 

PROVIDER: S-EPMC12712001 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature