Osteocalcin as a predictor of bone fracture in children with chronic kidney diseases.

ABSTRACT:

Background

The associations between biochemical indicators of osteocalcin and bone health are fairly well established in adults through observational studies. In this context, our objective was to assess serum level of uncarboxylated osteocalcin (uOC) and its relation to the incidence of bone fractures other bone health indices in children with CKD.

Methods

We enrolled 102 patients classified into two groups: group A: CKD without KRT; group B: CKD on regular HD. The patients were followed throughout the study period. The study's endpoint was either the occurrence of a bone fracture or the conclusion of the study period. Another 22 healthy individuals were involved as a control group. We measured uOC and various indicators of bone health including bone-specific alkaline phosp

SUBMITTER: Sawires H 

PROVIDER: S-EPMC12712007 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature