LINC01063 promotes colon cancer progression via the miR-134-5p/KRAS axis and serves as a prognostic biomarker.

ABSTRACT:

Background

Despite advances in treatment, the prognosis of colon cancer is still unsatisfactory, and there is an urgent need for reliable biomarkers and mechanistic studies. The role of long non-coding RNAs (lncRNAs) in tumor progression is well established, but the prognostic value and mechanism of LINC01063 in colon cancer are unclear.

Methods

We analyzed samples of colon cancer tissues and paracancerous normal tissues from 116 patients and performed functional experiments in the RKO/HCT116 cell line. The expressions of LINC01063 and miR-134-5p were measured using qRT-PCR. Clinical significance was assessed by statistical methods, and their interactions were verified by dual luciferase assay. The biological effects were evaluated by CCK-8, Transwell, and apoptosis assays.<

SUBMITTER: Liu Q 

PROVIDER: S-EPMC12712277 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature