The prognostic role of the neutrophil-to-lymphocyte ratio in metastatic urothelial carcinoma.

ABSTRACT:

Background

Systemic inflammation has been linked to cancer progression and survival outcomes. The neutrophil-to-lymphocyte ratio (NLR) is a readily available biomarker that may reflect this process in metastatic urothelial carcinoma (mUC).

Objectives

To evaluate the prognostic impact of baseline NLR on overall survival in mUC patients receiving chemotherapy or immunotherapy.

Design

A multicenter retrospective cohort study.

Methods

We retrospectively analyzed 196 patients with advanced, unresectable urothelial carcinoma treated at four centers (Ankara University School of Medicine, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara Bilkent City Hospital, and Gazi University School of Medicine) between 2005 and 2023. These patients w

SUBMITTER: Balli S 

PROVIDER: S-EPMC12712301 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature