Long-term human papillomavirus genotype-specific risk of cervical high-grade intraepithelial lesion and cancer-By age group and triage cytology.

ABSTRACT: Human papillomavirus (HPV) genotypes possess different cervical high-grade intraepithelial lesion and cancer (CIN2+) risks. HPV genotyping is a promising method to increase the specificity of primary HPV screening, but the optimal management of the infections with different genotypes has not been established. We aimed to assess long-term HPV genotype-specific CIN2+ risks, stratified by age and triage cytology result in a population-based cervical cancer screening program. This is a prospective study of 5253 HPV-positive individuals from the Finnish randomized HPV screening trial, with up to 18 years of follow-up. HPV-positive samples were genotyped using Luminex and BD Onclarity assays. The genotyping data were linked to data from four different nationwide health registries. The primary ou

SUBMITTER: Vahteristo M 

PROVIDER: S-EPMC12712356 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature