Enhanced diagnostic accuracy of high-grade cervical intraepithelial neoplasia in postmenopausal women through PAX1/JAM3 methylation analysis.

ABSTRACT: This study aimed to assess the diagnostic-support and triage value of PAX1/JAM3 methylation testing for identifying high-grade cervical lesions among postmenopausal women referred for colposcopy. A total of 216 women aged ≥50 years who underwent colposcopy due to positive high-risk human papillomavirus (hrHPV)/cytology detection and/or abnormal clinical symptoms were included, and 212 women aged <50 years matched 1:1 by hrHPV and cytology results as the control group. The effectiveness of PAX1/JAM3 methylation in detecting high-grade cervical intraepithelial neoplasia (CIN) was compared to traditional screening methods. PAX1/JAM3 methylation showed a sensitivity of 93.2%[85.7%-100%] for detecting CIN2+ lesions (97.2%[91.9%-100%] for CIN3+), with a specificity of 93.6%[89.9%-97.3%] for CIN1

SUBMITTER: Peng H 

PROVIDER: S-EPMC12712368 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature