Magnetic resonance imaging features of hypophysitis in patients with cancer treated with immune checkpoint inhibitors.

ABSTRACT: Immune checkpoint inhibitors (ICIs) have significantly improved outcomes in several solid malignancies but are associated with endocrine immune-related adverse events (irAEs), particularly hypophysitis. This retrospective real-world data study aimed to assess the magnetic resonance imaging (MRI) findings in cases with immune-related (ir) hypophysitis. Sixty-six cancer patients treated with ICIs at Laikon General Hospital between January 2016 and September 2024, presenting with anterior pituitary hormone deficiencies, were included. All patients underwent baseline pituitary MRI at the time of ir-hypophysitis diagnosis (median time: 2 weeks post-diagnosis). A follow-up MRI was also available in 37 patients (median time: 1.6 years post-diagnosis). All scans were centrally reviewed by radiolog

SUBMITTER: Angelousi A 

PROVIDER: S-EPMC12712373 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature