Mass Spectrometry of Minimal Change Disease and Focal Segmental Glomerulosclerosis.

ABSTRACT:

Introduction

The relation between minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS) (pFSGS) remains debatable, and the recent discovery of antinephrin and antislit antibodies, supports the hypothesis of a continuum disease. However, the overall expression of podocyte proteins in these disease states is not known.

Methods

In this observational proteomic study, we used laser microdissection and mass spectrometry (LMD/MS) to determine the proteomic profile of podocyte proteins in kidney biopsies of adult patients with MCD (n = 6), pFSGS (n = 7), secondary FSGS (sFSGS) (n = 10), and genetic FSGS (gFSGS) (n = 6). Time-zero kidney transplant (T0) (n = 6), IgA nephropathy (IgAN) (n = 5) and membranous nephro

SUBMITTER: Fervenza FC 

PROVIDER: S-EPMC12712510 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature