Randomized Trial of Twice-Weekly Versus Thrice-Weekly Hemodiafiltration for Initiation of Renal Replacement Therapy.

ABSTRACT:

Introduction

This study presents the first randomized controlled trial (RCT) comparing incremental hemodiafiltration (HDF) (i-HDF), beginning with twice-weekly sessions, to conventional thrice-weekly HDF (c-HDF) in incident dialysis patients with preserved residual kidney function (RKF): urea clearance (KrU) ≥ 2.5 ml/min.

Methods

In this multicenter, open-label trial, 150 patients were randomized 1:1 to either i-HDF (n = 77) or c-HDF (n = 73), regardless of comorbidity burden. The primary outcome was the decline in glomerular filtration rate (GFR) over 12 months. Secondary outcomes included changes in RKF (measured by 24-hour urine output, KrU, and creatinine clearance [KrCr]), incidence of anuria, hospital admissions, mortality, quality of life (using the Kidn

SUBMITTER: Fernandez Lucas M 

PROVIDER: S-EPMC12712586 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature